|
KMID : 1044820170470020086
|
|
Journal of Periodontal & Implant Science
2017 Volume.47 No. 2 p.86 ~ p.95
|
|
|
Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits
|
|
Joo Myung-Jae
Cha Jae-Kook
Lim Hyun-Chang
Choi Seong-Ho
Jung Ui-Won
|
|
|
Abstract
|
|
|
Purpose: The aim of this study was to determine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded synthetic bone substitute on implants that were simultaneously placed with sinus augmentation in rabbits.
Methods: In this study, a circular access window was prepared in the maxillary sinus of rabbits (n=5) for a bone graft around an implant (Ø 3×6 mm) that was simultaneously placed anterior to the window. Synthetic bone substitute loaded with rhBMP-2 was placed on one side of the sinus to form the experimental group, and saline-soaked synthetic bone substitute was placed on the other side of the sinus to form the control group. After 4 weeks, sections were obtained for analysis by micro-computed tomography and histology.
Results: Volumetric analysis showed that the median amount of newly formed bone was significantly greater in the BMP group than in the control group (51.6 mm3 and 46.6 mm3, respectively; P=0.019). In the histometric analysis, the osseointegration height was also significantly greater in the BMP group at the medial surface of the implant (5.2 mm and 4.3 mm, respectively; P=0.037).
Conclusions: In conclusion, an implant simultaneously placed with sinus augmentation using rhBMP-2-loaded synthetic bone substitute can be successfully osseointegrated, even when only a limited bone height is available during the early stage of healing.
|
|
|
KEYWORD
|
|
|
Bone substitutes, Collagen, Dental implants, Recombinant human bone morphogenetic protein-2, Sinus floor augmentation
|
|
|
FullTexts / Linksout information
|
|
|
|
|
Listed journal information
|
|
  
|